Wednesday, May 20, 2020

Lung Cancer A Malignant Transformation And Growth

Lung Cancer Screening Lung cancer is a malignant transformation and growth of the cells of the lung and the airway tissues. It is usually divided into two main types: Small Cell Lung Cancer (SCLC, 15%) and Non-Small Cell Lung Cancer (NSCLC, 85%) with the latter further subdivided into several subtypes such as Squamous, Large Cell, and Adenocarcinoma among other rare subtypes. Each subtype has its own unique growth and spread pattern with some being more aggressive than others. Lung cancer is staged according to the American Joint Committee by the TNM system, where T stands for the size, N for nodal involvement and M for the presence of distant metastases. The knowledge of the lung cancer main types, subtypes and stage, and the presence of specific molecular and genetic signatures, help the clinician determine the treatment approaches be it surgical, radiation, chemotherapy and the combination of, in addition to the appropriate type of chemotherapy. Lung cancer has been the most common cancer in the world for several decades. The International Agency for Research on Cancer (IARC) estimates for 2012 was 1.8 million new cases which constituted 12.9% of the total number of new cancers diagnosed worldwide. Fifty eight percent of which occurred in the less developed regions. Lung cancer remains the most common cancer in men worldwide (1.2 million, 16.7% of the total) with the highest estimated age-adjusted incidence rates in Central and Eastern Europe (53.5 per 100,000) andShow MoreRelatedLung Cancer : A Malignant Cellular Transformation And Growth Of The Lung And The Airway Tissues3080 Words   |  13 Pages Lung cancer is a malignant cellular transformation and growth of the lung and the airway tissues. It is usually divided into two main types: Small Cell Lung Cancer (SCLC, 15%) and Non-Small Cell Lung Cancer (NSCLC, 85%) with the latter further subdivided into several subtypes such as Squamous carcinoma, Large Cell carcinoma, and Adenocarcinoma among other rare subtypes. Each subtype has its own unique growth and spread pattern with some being more aggressive than others. Lung cancer is staged accordingRead MoreEssay about Cancer1518 Words   |  7 PagesCancer   Ã‚  Ã‚  Ã‚  Ã‚  Right now, cancer is one of the most feared diseases in the world. In the early 1990s almost 6 million new cancer cases developed and more than 4 million deaths from cancers occurred. Also more than one-fifth of all deaths were caused by cancer and it has been predicted, by the American Cancer Society, that about 33% of Americans will eventually develop this disease. This is a huge disease that is killing people all over the world.   Ã‚  Ã‚  Ã‚  Ã‚  The field of cancer study is called OncologyRead MoreThe Four Main Types Of Blood Cancers814 Words   |  4 PagesThere are four main types of blood cancers: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL). AML and ALL can become fatal within in a few weeks or month if not properly treated. CML and CLL has a slower progression rate than there chronic counterparts. Patients with AML or ALL tend to have noticeable symptoms whereas patients with CML or CLL tend to be asymptomatic (Hallek, 2015). Even though chronic leukemia progressesRead MoreNeoplasia10526 Words   |  43 PagesFMCPath) Senior Lecturer and Consultant Histopathologist University of Uyo Teaching Hospital,Uyo, Akwa- Ibom State, Nigeria. Neoplasia means the process of new growth whilst Neoplasm means a new growth. Sometimes, the parenchyma cells stimulate the formation of an abundant collagenous stroma, referred to as desmoplasia. Some tumours e.g. some cancers of breast are stony hard or scirrhous. Sarcomas have little connective tissue stroma and so are fleshy. Pseudo tumours: i) An ectopic rest of normal tissueRead MoreThe Expression Of Empiric Classic Emt Structural And Mesenchymal Biomarkers1466 Words   |  6 Pagesdifferentiate into two different types; Type-2 EMT (pro-fibrogenic) in small airways and Type-3 EMT (more pro-malignant) in large airways. This is consistent with the major pathologies associated with each compartment i.e. fibrosis and indeed obliteration in the small airways (2mm internal diameter), which is responsible for the main physiologic change of airflow limitation in COPD, with classically more cancer development in large airways, [23, 27, 28] especially for the squamous cell variety. Previous studiesRead MoreCancer : The Most Important Causes And Complications Of Breast Cancer1048 Words   |  5 PagesBreast cancer is the most prevalent cancer identified in women, and in spite of substantial developments in cancer treatment, it is still the second most important cause of cancer-related deaths. In general, up to 25% of breast cancer patients overexpress HER2 gene. Recently, the mAbs that identify antigens on cancer cells are being used for the targeted therapy of cancer. The antibodies can be used alone or as conjugates for the transport of radioisotopes, toxins, or drugs. Immunotoxins are manufacturedRead MoreAnticancer Drugs And Its Effects1279 Words   |  6 Pagesdrugs that showed phenomenal transformation in cancer management, unfortunately chemoresistance has been developed which represents the main reason behind chemotherapy failure in the most common types of cancer such as: lung, colon, and breast; it’s considered to be a major problem in Oncolog y. Chemoresistance is simply when rapidly growing cancer cells that used to be affected and destroyed by antineoplastic drugs stop responding and start to grow again. When cancer cells are tolerated to some anticancerRead MoreMatrix Mettaloproteinase 3 : A Potential Biomarker For Human Metastatic Osteosarcoma1711 Words   |  7 Pagesexpression of MMP-3 in human osteosarcoma and associated with tumor metastasis Abstract: Matrix metalloproteinase-3 (MMP-3, is one of several matrix metalloproteinases (MMPs) family that has been observed in several malignant tumors, including breast, colon, cervical and lung cancers, where its expression correlates with the invasion and metastasis of these tumors. However, the roles of MMP-3 in osteosarcoma are totally unknown. In this study, we examined the expression of MMP-3 in 15 primary andRead MoreAdjuvants In Vaccines1587 Words   |  7 PagesThe viruses that cause tumorigenic transformation produce oncoviral antigens. These antigens are recognized by the immune system as â€Å"non-self† because they are present on infected cells (Saxena and Bhardwaj 2017). Neoantigens, which are MHC restricted antigens, are produced by mutations in tumor cells so they are not found on all tumors. Because neoantigens are unique to the individual, vaccines that target these antigens need to be personalized (Saxena and Bhardwaj 2017). Finally, antigens thatRead MoreCancer Immunology2728 Words   |  11 PagesCancer: Cancer can be defining as disease condition in which cell divide and proliferate uncontrollably bypassing the normal rules of cell division. It is characterized by a progression of changes on cellular and genetic level that ultimately reprogram a cell to undergo uncontrolled  cell division, thus forming a malignant mass. Carcinogenesis: Cancers consist of single clones or several clones of cells that are capable of partially (benign tumor) or fully (malignant cancer) independent

Wednesday, May 6, 2020

Unemployment And Its Impact On The Pakistan Economy Essay

INTRODUCTION Unemployment is one of the most difficult social issues of market economics. The unemployment shifts over the business cycles as understood as changes in aggregate demand relative to aggregate supply. This paper deals with the information and the causes of unemployment and its impact on the Pakistan economy. It also shows different aspects and reasons for growing unemployment in Pakistan including its prevailing economics crisis. The role of government is also taken care of to identify the causes of unemployment. The research is conducted about the impact of unemployment on Pakistan economy. Study identifies the economic reasons of unemployment in Pakistan, to search unemployment in Pakistan and Effects of social economic impact on youth of Pakistan. The research gives information of various reasons for unemployment and its impact on the economy of Pakistan. Those who have abilities and the will to do work, but there is lack of opportunities to get job are in the category of unemployed. When unemployment high resources are wasted, people’s income are depressed. In the current situation the ratio of unemployed persons in Pakistan is more than 12 percent which consists of 113 million peoples. (Nizami.S; 2010) According to latest labour survey for 2008-09, the unemployment rate has increased to 55% from 52% unemployment rate as 15 percent. (Khalil; 1999) There are so many reasons of unemployment in Pakistan. The biggest reason is the insufficient methods ofShow MoreRelatedPhillips Curve Methodology Is Used On An Information Set Of 35 Years Essay1623 Words   |  7 Pagesnation like Pakistan, Phillips Curve methodology is utilized on an information set of 35 years. Phillips Curve helps in analyzing the relationship in the middle of inflation and unemployment. There is a non-relative negative relationship in the middle of inflation and unemployment (if unemployment is decreased than there is a rising value level in the economy). There is a long-run and easygoing relationship in the middle of inflation and unemployment over the above-mentioned period in Pakistan. ThereRead MoreReport On The Unemployment Of Pakistan Essay1016 Words   |  5 Pages Report on: Unemployment in Pakistan Submitted by: Aneel kumar Submitted to: Sir Muhammad Yamman khan Class BBA-III (morning) Subject: Business communication University of Karachi ACKNOWLGEMENT: I am grateful to my Sir Muhammad Yamman Khan who gave me this chance to write a report. By which I got my first experience to working on a report. I have taken efforts in this report and however It would have not been possible without the kind support and help of my relatives and friends so thanksRead MoreConclusion of Corruption1522 Words   |  7 PagesPakistan and its Chronic Unemployment Pakistan is a nation that has been plagued by many problems throughout it’s more than 6 decades of existence. But one problem that has plagued it persistently is that of unemployment. It has an unemployment rate of 15.4% and ranks on 152/199 on the world employment table. Having one of the world’s largest populations also means that this 15.4% is a very large number in its own right. Now we know some basic problems as to why there is so much unemployment inRead MoreThe IMF Disease Eating Away Our Daily Bread946 Words   |  4 PagesThe IMF disease eating away our daily bread Pakistan’s economy has paid a huge price in partnering the war on terror with the USA. According to a recently released IMF report called â€Å"Pakistan Poverty Reduction Strategy Paper†, total losses, measured in terms of exports, foreign investment, industrial output and tax collection, are estimated to be around RS 2.08 trillion during the last five years period. The war on terror has outbalanced already stretched financial resources of the governmentRead MoreGlobalization1305 Words   |  6 Pagesï » ¿Globalization, by definition, is the integration and democratization of the world s culture, economy, and infrastructure through transnational investment, rapid spread of communication and information technologies, and the impacts of free-market on local, regional and national economies. The golden words of late Dr. Mahbub ul Haq provides the true vision: Globalization is no longer an option, it is a fact. Developing countries have either to learn to manage it far more skilfully, or simplyRead MoreGlobalization And Its Impact On Pakistan s Economy978 Words   |  4 Pages SYNOPSIS Topic: Globalization and its impact on Pakistan’s economy Submitted to: Miss Ayesha Submitted by: Syeda Fatima Nadir Semester: 6 Major: Economics Introduction: Globalisation is the processRead MorePoverty in Pakistan: Causes and Consequences1610 Words   |  6 Pagesrepresentation and freedom. Pakistan is a low income developing country. In Pakistan, like other developing countries, poverty is grave concern for the government and policy makers. Pakistan, after its independence, has experienced highs and lows of economic growth with increase and reduction in poverty. There is also a big difference in poverty levels between rural and urban places in Pakistan. This difference in poverty levels is due to the structure of Pakistan’s economy and the way this economicRead MoreImpact Of Globalisation On The Economic Development Of Pakistan1073 Words   |  5 Pagesthe biggest positive sides of globalisation in Pakistan. However, increase in the rate of unemployment has also been witnessed as a negative feature associated with the industrialisation and globalisation of Pakistan’s economy. This paper discusses the real aspects of globalisation in Pakistan by determining the economical, social, cultural and environmental effects on its economy. The impact of globalisation on the economic development of Pakistan will be discussed with an explanation of both,Read MoreInflation, Unemployment and Poverty: Still Major Problems of Pakistan2585 Words   |  11 PagesInflation, Unemployment and Poverty: Still Major Problems of Pakistan Zoha Siddique Forman Christian College University Since Pakistan came into being, it’s going through hard times. From newly born country to getting sixty four year old country, sometimes it has given sacrifices and sometimes remained victim of inapt political system. For the long time, it is facing number of challenges and conspiracies which has weakened its foundations and so is the structure. Therefore,Read MoreImpact of Terrorism in Pakistan1628 Words   |  7 PagesImpact of Terrorism in Pakistan In lieu of unlawful violence to inculcate fear and increase coercion, terrorism has become a trending topic in the world today. Pakistan, a country in South Asia bordered by Afghanistan and India has been a country worthy of speculation due to the rate of terrorism and tribal wars that have quickly taken over the country. The sporadic effects of these attacks have begun to shatter what used to be one of Asia’s fastest growing economies. Impact on GDP Pakistan’s

Civil Procedure for Journal of the Profession- myassignmenthelp

Question: Write about theCivil Procedure for Journal of the Legal Profession. Answer: Facts Happy Girls was started by Moore as a pet minding enterprise in the year 2010. After growing a good reputation and getting fund, Moore adopted the business name to cater mostly to exotic fish. She took help from Otto Chubbs to establish a website platform for the business. Moore entered into a written contract with Gogol which helped Moore in expanding her pet service business. The Agreement entered between the parties was to be valid till June 30, 2020 which would entail the exclusivity of Happy Girls. The agreement between the two parties helped them grow financially. An incident occurred on December 13, 2017 when Moore visited a first-time client Gavin, who owns an alligator named Grandma. The agreement was to care for Grandma for 6 weeks. Grandma was a toothless and one-eyed which was clearly mentioned in the instructions. The agreement also mentioned that Grandma was kept in a designated, secure aquatic sanctuary. McChuter was in a hurry to leave for Dubai and therefore he forgot to close the gate of the sanctuary when he left. Moore tried her best to send the alligator back to the sanctuary but failed to do so. Moore, with food in her hand tried to send the alligator back to the sanctuary but Grandma lunged at her and though she was toothless, the force with which Grandma jumped at her, she suffered injury and her bones were crushed. The doctor has given Moore an estimate of $915 and due to the injury, Moore cannot join work. Furthermore, the incident of attack which was captured by a private surveillance was seen at Gogols video sharing site Portrait. Even Moore tried to contact Gogol to take the image off the website but he did not listen to her and later found that they were tagged at hilarious pet videos. Otto, who had initially helped Moore with the website, claimed that a t-shirt which was given to Moore by him has been sold to Gogols platform without his permission. In the present case, Moore wants to bring legal action against Gogol, Gavin and Otto for infringing her privacy and breaching confidentiality, for not respecting the terms of the agreement signed between the parties. Cause Of Action Cause of action under the UPCR is not a formal legal document, but a litigators take on a legal situation to gauge if substantive area of law can be made out or not[1]. In the present case, a legal action can arise against Gogol , Gavin and Otto. Gogol Clause 19 of the agreement between Gogol and Moore talk about Termination. The clause for termination is as being a material breach of obligations or when one of the parties does anything that is against the interests of the aggrieved party. The agreement between Moore and Gogol also talk about the clause of confidentiality wherein the parties have to respect the privacy of the other party and also use any information for the purpose of the agreement and nothing beyond the scope of the same. Clause 40 of the agreement specifically deals with confidentiality, that is, no information shall be made available to the public domain without the consent of the other party. Clause 45 of the agreement mentions the term of good faith, that is, the clause of utmost due diligence shall be meted out to the other party to ensure that the terms of the contract are not reached. Keeping in mind all the three clauses of termination, confidentiality and good faith that has been agreed between the two pa rties to treat the contact fairly, Moore has a cause of action against Gogol. The terms of the agreement were fixed to ascertain the relation between Gogol and Moore and by uploading the video of attack and tagging the photo in hilarious pet videos, Gogol has breached the privacy clause and has acted against the terms of the contract. The terms of the contract entail that the party shall not act in contravention of the best terms of the contract and in cases any party tries to breach, the termination clause shall be applied. Moore has tried every way possible to get in touch with Gogol to ask him to remove the video, but Gogol has not answered his calls. All calls made to Gogol and all emails to him have not been answered. Again, the basic idea behind enforcing the good faith clause is to ensure that parties act in accordance with the due diligence clause and try to respect the terms of the contract in the best of their ability. By uploading a personal video to the public domain, an d also by not answering the calls and emails, Gogol has breached the terms of the contract and therefore, the contract can be breached in accordance with clause 19 of the Contract because the obligations of the agreements have not been met. Gavin Gavin was the client of Moore and as part of duty, Moore had to take care of the alligator Grandma who was toothless and whose care mandated that he be put in the sanctuary which was not taken care of by Gavin because he had left in a hurry keeping the door of the sanctuary open. Due to the failure on the part of Gavin, the door of the sanctuary was left open and as a result Moore found it difficult to put the alligator back to the sanctuary. After trying hard with food in her hand, Moore tried to put the alligator back and as a result she suffered severe injuries due to which she suffered economical as well as psychological harassment. Gavin was negligent in keeping the door open, resultant of which Moore suffered the injuries. Gavin has been in Dubai since the incident and has not returned to Australia. Australian laws have process convention with USA, but not with Dubai. No process convention can place between Australia and Dubai and since Gavin is in Dubai, no charges can be brou ght against him till he comes back to Australia. Otto Otto, the cousin of Moore had helped her set up the website and later demands a sum of $10,000 for selling a specifically designed tshirt to the website of Gogol. Moore does not have any record of transactions with Otto but clearly remembers that Gogol has not used any photo given by Otto to Moore because he has his own sophisticated website. Since, the terms of the agreement are not recorded with Moore anymore; the onus is on Otto to prove that the designs provided by Otto have been misused. Moore has already made an agreed amount of payment for the work and is certain that no design has been misused by Gogol or Moore. Joinder of causes of action and parties The test to be followed while claiming a joinder of parties[3] is that, There should be common question of fact or law in the proceedings Same transaction or events of series of transaction Leave of court In this case, there are 3 a series of events that fall under the same transaction and are related by facts, hence the principle of joinder of parties will apply. Bendir v Anson[4] laid down that whenever same question of fact or law arises in the same transaction, the facts can be joined in the same proceedings. Jurisdiction Of Court In this case, the parties are related by the same chain of events and transaction and are governed by joinder of parties. A joinder of parties is triable by the Supreme Court[6]. In this case, the Supreme Court of Australia has jurisdiction to try the case. This is a civil dispute by nature and since there has been a breach of contract, there will be fixation of damages by the Court. In cases of civil dispute, the aggrieved party is compensated by paying damages. Originating Process Part 10.3 deals with service of originating process in Australia[8]. This applies to all the proceedings taking place in Australia. Service is the formal process of notifying the other party about sending the documents. All documents related to the document need to be sent to the defendant as per the rules of the UPCR. The service of documents is done to ensure that the legal documents that are necessary for the proceedings are sent to the other party as per the rules[9]. Originating Process[10] is the initial service before the commencement of the proceedings. The original application needs to be served to the other party who are parties to the proceedings[11]. Originating Process can be served personally by handing over the documents to the other party. Part 10.14 states that a document shall be served on a party by the court when the service cannot be served in the normal course[12]. References Bartlett, Francesca. "Making lawyers pay for malpractice in court: skirting advocates immunity in Australia."International Journal of the Legal Profession24.2 (2017): 109-123. Bendir v Anson [1936] 3 All ER 326 CGU Insurance v Bazem Pty Ltd[2011] NSWCA 81. Dhagamwar, Vasudha. Towards the uniform civil code. Indian Law Institute, New Delhi, 2015. Uniform Civil Procedure Rules, 2005 White, Ben, et al. "Estate contestation in Australia: An empirical study of a year of case law." UNSWLJ 38 (2015): 880.

Thursday, April 23, 2020

Portfolio of the Cultural Perception in the Fine Art

Drawing is a crucial element of visual arts since it constitutes a noteworthy element of fine art. Evidently, a drawing highlights crucial information about the object under study.Advertising We will write a custom essay sample on Portfolio of the Cultural Perception in the Fine Art specifically for you for only $16.05 $11/page Learn More It also shuns the use of words in recounting occurrences in real life. Modern drawings make use of ‘dry’ or ‘wet’ media; furthermore, drawings do not significantly differ from painting. During the drawing process, it is important to look at the connection between the vertical and horizontal lines of the image. The identification of the angle is tenable using a compass. It is remarkable to note that the measuring process lacks significance. Additionally, the pose of grasping the pencil is crucial during illustration. An example is evident when the vertical line is placed against the second line to form an angle. This determines the accuracy of the angle under formation. During the course of coming up with angles, it is important to shun the preconceived knowledge concerning the object. Instead, the artists should create new ideas to bring out the subject in a real situation. Proper consideration of the layout as evident in accurate joints makes the drawing appear real. Evidently, figures such as portraits attain proportionality. When drawing figures to exemplify three-dimensional aspects, it is important to darken the regions that are further from the light. This reflects the tone of the drawing. The direction of light influences the side of image with the shadow. Interestingly, the strength of the light influences the shade of the shadow. Additionally, lighting in the drawing also affects the feeling created by the figure. Two lighting aspects influence the ‘mood’ of a drawing. This incorporate the direction of lighting, and the magnitude of the light. During high intensity, light may blur some element of texture thus creating a perception.Advertising Looking for essay on art? Let's see if we can help you! Get your first paper with 15% OFF Learn More Composition is a significant aspect when producing quality artwork. Plans are initiated while organizing each of the image’s elements in a proper way thus communicating the mood/feeling to the observer. The positioning of the image together with the lighting will influence the feeling, which comes to the artist’s mind. In essence, the artist’s ideas ought to exemplify the viewer’s perceptions. The distance of the main figure relative to other figures in the drawing is an imperative element in art. This aspect influences the size and the ‘negative space’ in the drawing. This is an important feature in presentation of the drawing since it highlights important themes in the background. The arrangement in the background and emphasis on obje cts highlights the message, which the artist aims to communicate. Indeed, motion becomes articulate with the intention of passing appropriate information. Conclusively, drawings highlight the cultural setting of the artist. For example, aspects of religion may arise as the theme, which the artist intends to highlight. The drawing may represent a deity, group worshippers, and worship places. Music/dance may become manifest after studying an artistic drawing. It is worth denoting that music and worship are subject to separate or comprehensive consideration. Concurrently, drawings on nature may show the geographical background of the artist. This may be an important hint, which may highlight his home setting. Additionally, it may offer a suggestion on the gender roles in the society. Interestingly, economic activities may show how the subjects make their income and the core pillars of the economy. Concisely, the artist may choose the cultural perception she wants to create in the viewe r. Summarily, fine art is incomplete without drawing. Therefore, perfection of the art is important to enhance reality in drawings.Advertising We will write a custom essay sample on Portfolio of the Cultural Perception in the Fine Art specifically for you for only $16.05 $11/page Learn More This essay on Portfolio of the Cultural Perception in the Fine Art was written and submitted by user Jamie Stephenson to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Tuesday, March 17, 2020

Colorado School of Mines GPA, SAT ACT Requirements

Colorado School of Mines GPA, SAT ACT Requirements Admission to Colorado School of Mines is selective, and in 2015, only 38% of all applicants were admitted. To get in, youre going to need grades and standardized test scores that are well above average. In the scattergram above, the blue and green dots represent accepted students. You can see that the majority of successful applicants had high school averages of 3.5 or higher, SAT scores (RWM) of about 1200 or higher, and ACT composite scores of 24 or higher. The higher those numbers, the better your chances of receiving an acceptance letter. The average ACT composite for accepted students is 30. Note that there are many red dots (rejected students) and yellow dots (waitlisted students) hidden behind the green and blue throughout the graph. Many students with grades and test scores that were on target for Colorado School of Mines did not get in. Note also that a few students were accepted with test scores and grades a little bit below the norm. This is because Mines uses has holistic admissions admission decisions are based on more than numerical data. The Mines application asks for information about your extracurricular activities and awards, and you also have the opportunity to provide a personal statement. The college also pays close attention to the rigor of your high school courses, especially in math. How Do You Measure Up? Calculate Your Chances of Getting In with this free tool from Cappex. To learn more about Colorado School of Mines, high school GPAs, SAT scores and ACT scores, these articles can help: Colorado School of Mines Admissions ProfileWhats a Good SAT Score?Whats a Good ACT Score?Whats Considered a Good Academic Record?What is a Weighted GPA? If You Like Colorado School of Mines, You May Also Like These Schools   Stanford University:  Profile  |  GPA-SAT-ACT GraphCornell University:  Profile  |  GPA-SAT-ACT GraphCal Poly:  Profile  |  GPA-SAT-ACT GraphCarnegie Mellon University:  Profile  |  GPA-SAT-ACT GraphPurdue University:  Profile  |  GPA-SAT-ACT GraphHarvey Mudd College:  Profile  |  GPA-SAT-ACT Graph

Sunday, March 1, 2020


Nonplussed Nonplussed Nonplussed By Maeve Maddox The Latin phrase non plus, â€Å"not more, no further,† entered English as a noun with the following meaning: A state in which no more can be said or done; inability to proceed in speech or action; a state of perplexity or puzzlement; a standstill. As a verb, to nonplus means, â€Å"to bring to a nonplus or standstill; to perplex, confound.† In modern speech, the verb is most commonly seen in the participle form nonplussed. Until about the 1960s, nonplussed was used with only one meaning: Brought to a nonplus or standstill; at a nonplus; perplexed, confounded. Since the 1960s, nonplussed has taken on another meaning for some English speakers: Not disconcerted; unperturbed, unfazed. The OED mentions this second meaning in its entry for nonplussed, labeling it â€Å"chiefly American.† The recognized authority for American usage, however, does not list this second meaning of nonplussed. It doesn’t even have an entry for nonplussed. The verb nonplus is defined this way: â€Å"to cause to be at a loss as to what to say, think, or do; reduce to a state of total incapacity to act or decide.† Merriam-Webster gives three examples: this turn of events nonplusses me nonplussed by the disclosure for a moment the girl was nonplussed The reversal of meaning from perturbed to unperturbed has arisen from the mistaken idea that the non- in nonplussed is a prefix, like the non- in nontoxic. Some speakers seem to think that nonplussed is formed by adding non- to the hypothetical root plussed. US speakers do use nonplussed with the original meaning: May 16, 2015   When invited to come here I was flattered, but  a bit nonplussed.- Charles Gibson, US journalist, 2015. Many consumers nonplussed, confused with latest tech, survey finds- Automotive News, (published in Michigan), 2015. However, most of the recent examples of nonplussed that I have found in US sources use it in the sense of unfazed, unimpressed, or unmoved. For example: Uber Driver Nonplussed After Giving Jeb Bush Ride in San Francisco- NBC News. (According to the article, the driver was unimpressed.) â€Å"I’m in first place by a lot, it seems, according to all the polls,† Trump says, in his New York accent, with his usual facial expression: a sort of perpetually nonplussed duckface, like he is continually being impressed with himself anew.- Atlantic Monthly, 2015. Nonplussed, Colbert has kept up his usual antics.- CBS News, 2015. Unlike self-antonyms like dust and sanction, whose meanings are usually clear from context, nonplussed is a source of ambiguity. The phrases â€Å"dusting the furniture† and â€Å"dusting the crops† require no additional qualification; the different meanings are immediately apparent. A statement like â€Å"the defendant was nonplussed,† however, means one thing to one English speaker and the opposite to another. Take, for example, this statement in the clinical study of a disturbed teenager: He appeared nonplussed when  the issue of the family cat was raised.- Francis D. Kelly, The Assessment of Object Relations Phenomena in Adolescents, Routledge, 2014. The boy was in treatment because, among other disturbing behavior, he had killed the family cat. When I read the sentence, I understood it to mean that the mention of the cat caused the boy to exhibit signs of confusion. On second thought, I realized that the author may have intended nonplussed to mean unmoved. Authors of serious works cannot afford to use nonplussed without providing context clues to indicate which meaning is intended. The following examples provide such clues: In an interview  with the CBS news magazine â€Å"60 Minutes,† Steve Schmidt described Palin as â€Å"very calm - nonplussed† after McCain met with her at his Arizona ranch just before putting her on the Republican ticket.  (nonplussed=unperturbed) Vance  appeared nonplussed  and genuinely surprised that such large political questions had been raised by the memorandum. (nonplussed=agitated) ODonnell appeared to be nonplussed by the wording of the first amendment, repeatedly returning to the subject and sounding incredulous after her Democratic opponent Chris Coons attempted to explain it to her. (nonplussed=confused) Because nonplussed no longer conveys the same meaning to all readers, writers must be thoughtful in its use. Accompanying the word with context clues is one option. Choosing a different word entirely is another. Some options for the meaning originally conveyed by nonplussed: perplexed, confounded, disconcerted, upset, agitated. Some options for the reversed meaning of nonplussed: not disconcerted, unperturbed, unfazed. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:Dialogue Dos and Don'tsFive Spelling Rules for "Silent Final E"How Do You Pronounce "Often"?

Thursday, February 13, 2020

Terry fox a canadian individual whose contribution made a difference Research Paper

Terry fox a canadian individual whose contribution made a difference in the lives of canadians or non-canadians - Research Paper Example He continued his run for 143 days during which he covered 5.373 kilometres in the country. The run ended up his life but gave him worldwide lasting legacy. The essay aims to discuss the contribution of Terry Fox who was an ordinary young man that turned to the national hero in Canada due to his remarkable contributions and efforts to insist Canadians to make some donation for cancer research. His efforts resulted in annual fund raising run in Canada as well as other countries of the world and the funds collected from the run are used for providing cancer patients with better treatment and cure through detailed research work. His contributions not only benefited the Canadians but the people outside the Canada also avail the benefits of the cancer research conducted with the help of funds and public awareness raised by his run (Murphy, 2005). Fox was a basketball player and distant runner. He played for the Port Coquitlam, British Columbia, high school and Simon Fraser University teams. He was diagnosed with osteosarcoma, a form of bone cancer in 1977 due to which his right leg was removed from his body at about six inches about his knee. He however continued to run with the artificial leg and also played wheelchair basketball in Vancouver and also won three national basketball championship events. The time he spent in the hospital was the worst time of his life that he always hated (Chivers, 2009). His experience made him realize that there is very little money spent in Canada for the cancer research that must be raised to bring improvement in the condition of people and help fighting the cancer patient with their disease. He decided to raise money and awareness all over the country to fight against cancer. He decided to insist the Canadians to donate one dollar for the cancer research. He persuades people that when 24 million Canadians will donate just one dollar it will help collecting around 24 million rupee